Genetics

This blog post examines a study investigating the performance of polygenic risk scores for predicting multiple sclerosis in individuals of South Asian ancestry. Using data from the Genes & Health cohort and comparing results with European-ancestry participants from UK Biobank, the article demonstrates that polygenic risk scores derived from European genome-wide association studies show reduced predictive accuracy in South Asian populations. The findings emphasize the scientific and clinical importance of ancestry-diverse genetic research, particularly as polygenic risk scores are increasingly considered for disease prediction, prevention trials, and future precision medicine strategies.