Genetics

This blog post examines recent evidence on the role of genetic variants in predicting disease severity and progression in multiple sclerosis, drawing on findings from a large, longitudinal, real-world cohort. By critically evaluating previously reported severity-associated genetic markers and polygenic risk scores, the analysis highlights the challenges of translating genome-wide association study results into clinically meaningful prognostic tools. The discussion underscores the importance of replication, rigorous phenotyping, and cautious interpretation when considering the clinical relevance of genetic predictors in complex neurodegenerative disorders.