Genetics

This blog post examines a 2023 Annals of Neurology study by Gasperi et al. that connects the multiple sclerosis severity-associated genetic variant rs10191329*A with accelerated brain atrophy. By analyzing longitudinal MRI data from independent discovery and replication cohorts, the study shows that this risk allele is associated with greater yearly brain volume loss, suggesting that inherited genetic differences may influence neurodegeneration and long-term disease severity in multiple sclerosis.