Genetics

This blog post walks through a study that connects multiple sclerosis (MS) genetics to the specific cells and regulatory DNA elements where risk appears to act. Rather than treating GWAS hits as abstract signals, the article follows how MS-associated variants cluster in enhancer and promoter regions—especially in B cells, monocytes, and brain-resident microglia—and how 3D genome maps help translate those variants into prioritized gene lists. It also summarizes the paper’s key quantitative results, including cell-specific gene counts and polygenic risk score performance, and closes by describing how cell-linked genetic burden relates to real-world outcomes like white matter volume and relapse activity.