Genetics

This blog post examines emerging evidence that the genetic variants predisposing individuals to multiple sclerosis are largely distinct from those influencing long-term disease severity, progression, and tissue damage. Drawing on recent findings in clinical genetics, neuroimaging, and biomarker research, it explores how susceptibility is primarily rooted in immune-related pathways, whereas outcome phenotypes appear to be more closely linked to central nervous system resilience and neurodegeneration.