Genetics

This blog post presents a systems-level analysis of multiple sclerosis based on a comprehensive study of autoantibody repertoires in relapsing–remitting MS patients before and during disease-modifying therapy. By integrating phage display–based immunoprofiling with protein interaction networks and pathway enrichment analyses, the article illustrates how early MS is dominated by immune activation, excitotoxic signaling, and inflammatory cascades, whereas treatment shifts the disease landscape toward altered lipid metabolism, energy sensing, and endocrine regulation. The post highlights key molecular pathways and network hubs that link immunity, metabolism, and neurodegeneration, offering insights into MS pathogenesis and potential directions for biomarker discovery and therapeutic innovation.