Genetics

This blog post examines how cumulative genetic risk contributes to multiple sclerosis susceptibility by analyzing large, multi-center family cohorts using an expanded polygenic risk framework. By integrating up to 64 established MS-associated genetic variants, the study evaluates differences in genetic burden between multi-case and single-case families, assesses the predictive limitations of genetic risk scores within families, and explores shared genetic architecture across clinical MS subtypes. The findings highlight both the strengths and inherent constraints of current polygenic models in capturing MS heritability and inform future directions for genetic risk modeling in complex autoimmune diseases.