Genetics

This blog post synthesizes recent GWAS and functional-genomics evidence suggesting that inherited risk for multiple sclerosis is not confined to peripheral immune cells and microglia, but also implicates CNS parenchymal cell types—most notably inhibitory neurons. Drawing on an expanded multi-cohort analysis and cell-type-resolved eQTL colocalization, it summarizes how newly refined susceptibility signals, a multi-ancestry polygenic score, and neuron-specific regulatory links at loci such as IL7 and STAT3 collectively motivate a revised etiologic framework in which immune dysregulation and CNS-intrinsic vulnerability are jointly causal.