Genetics

Three studies measure MS at three costs. Briggs and colleagues genotype 1,252 patients and find HLA-DRB1*15:01 raising the odds of gluten intolerance about 3.5-fold while a 198-variant risk score shifts childhood seasonal allergies by two percent per allele. Shi and colleagues find 25 serum lipids reproducibly higher in relapsing MS across two cohorts, but also higher in other neurological disorders, and measure phospholipase A2 directly to find it lower rather than raised. Zöchner and colleagues scan 20 patients at 7 T over three years and watch a myo-inositol ratio climb with rim lesion count.