Genetics

Optic neuritis is frequently the first clinical manifestation of multiple sclerosis, yet accurately predicting which patients will later develop MS remains a major clinical challenge. This blog post examines a recent large-scale genetic study that demonstrates how a multiple sclerosis genetic risk score, when combined with basic demographic factors such as age and sex, significantly improves prediction of future MS diagnosis at first presentation with optic neuritis. Drawing on data from the UK Biobank and validated across independent cohorts in the United States and Finland, the analysis highlights the potential of genetic risk stratification to refine early clinical decision-making, support precision-based treatment strategies, and enable earlier intervention aimed at reducing long-term neurological disability.