Genetics

This blog post examines recent evidence that inherited genetic burden may contribute to progression independent of relapse activity in multiple sclerosis. Based on the study by Clarelli and colleagues, it explores how polygenic risk scores linked to disease severity were associated with higher rates of silent disability accumulation, particularly in patients with earlier disease onset. The article highlights the growing importance of PIRA as a driver of long-term disability and discusses how genetic profiling may help refine future prognostic models for multiple sclerosis.