Genetics

This blog post examines emerging scientific evidence on the biological and environmental factors that influence multiple sclerosis severity. It highlights the contrast between the many genetic loci identified for MS susceptibility and the limited number linked to disease progression, with special attention to the DYSF–ZNF638 locus. The article also discusses how observational studies, Mendelian randomisation, and epigenetic research are reshaping our understanding of disability accumulation, neuroinflammation, CNS resilience, and future personalised therapeutic strategies in MS.