Genetics
Which Metabolites Cause MS? The First Metabolome-Wide Mendelian Randomization Study in MS12, Oct 2026
Topic hub
Omics Analysis
This pillar groups omics analysis posts that connect molecular measurements with disease mechanisms, biomarkers, and pathway-level interpretation.
Core Questions
Which molecular layers best explain disease biology?
How can pathway analysis turn high-dimensional results into interpretable mechanisms?
Where do omics findings suggest biomarkers or therapeutic hypotheses?
Topic Clusters
Core Articles
Genetics
Which Metabolites Cause MS? The First Metabolome-Wide Mendelian Randomization Study in MS
12, Oct 2026This post covers Ge and colleagues' 2023 metabolome-wide Mendelian randomization study in the Journal of Neuroimmunology, which tested 571...
Genetics
More Enzyme, Less Branching, and More MS Risk
11, Oct 2026This post covers Mkhikian and colleagues' 2011 Nature Communications study, which inverted the usual order of genetic work by screening...
Genetics
Multiancestry MS GWAS Meets Single-Cell and Spatial Data
11, Oct 2026This post covers Fujimoto and colleagues' 2026 Nature Genetics study, the first MS GWAS in an East Asian population and a four-population...
Genetics
An Energy Deficit in MS Lesions, and in Tissue Before It Demyelinates
10, Oct 2026This post reads Ladakis and colleagues' 2024 metabolomic study of MS brain lesions through its bioenergetic rather than its lipid findings. It...
Genetics
From an MS GWAS Locus to the Gene It Acts Through
08, Oct 2026This post covers the variant-to-gene half of Upcott and colleagues' 2026 medRxiv preprint, which paired the MS susceptibility GWAS with blood and...
Genetics
Single-Nucleus Profiles and Lesion Geography in the MS Cortex
08, Oct 2026This post covers Schirmer and colleagues' 2019 Nature study, which applied single-nucleus RNA sequencing and spatial transcriptomics to cortical...
Genetics
Metabolomics and Single-Nucleus Data From the Same MS Lesion
07, Oct 2026This post covers Ladakis and colleagues' 2024 study in Neurology: Neuroimmunology & Neuroinflammation, the first metabolomic profiling of MS brain...
Genetics
What This Year's Nobel Tool Has Done in MS So Far
06, Oct 2026This post covers Absinta and colleagues' 2021 Nature study, which used the paramagnetic rim MRI biomarker to direct single-nucleus RNA sequencing...
Genetics
The Metabolite Pathway Behind the MS Severity Variant
04, Oct 2026his post covers Nataf and colleagues' 2024 study in the International Journal of Molecular Sciences, which redoes the gene prioritization for...
Genetics
MS Risk Variants, Single Cell Expression, and MRI Brain Volume
02, Oct 2026This post covers Upcott and colleagues' 2026 medRxiv preprint, which builds cell-type specific transcriptional risk scores for MS by weighting...
Genetics
A Choroid Plexus Endophenotype for HLA Burden in MS
02, Oct 2026This post covers Preziosa and colleagues' 2026 study in Neurology: Neuroimmunology & Neuroinflammation as an imaging-genetics design. It follows...