Genetics
Multiancestry MS GWAS Meets Single-Cell and Spatial Data11, Oct 2026
Topic hub
Omics Analysis
This pillar groups omics analysis posts that connect molecular measurements with disease mechanisms, biomarkers, and pathway-level interpretation.
Core Questions
Which molecular layers best explain disease biology?
How can pathway analysis turn high-dimensional results into interpretable mechanisms?
Where do omics findings suggest biomarkers or therapeutic hypotheses?
Topic Clusters
Core Articles
Genetics
Multiancestry MS GWAS Meets Single-Cell and Spatial Data
11, Oct 2026This post covers Fujimoto and colleagues' 2026 Nature Genetics study, the first MS GWAS in an East Asian population and a four-population...
Genetics
An Energy Deficit in MS Lesions, and in Tissue Before It Demyelinates
10, Oct 2026This post reads Ladakis and colleagues' 2024 metabolomic study of MS brain lesions through its bioenergetic rather than its lipid findings. It...
Genetics
From an MS GWAS Locus to the Gene It Acts Through
08, Oct 2026This post covers the variant-to-gene half of Upcott and colleagues' 2026 medRxiv preprint, which paired the MS susceptibility GWAS with blood and...
Genetics
Single-Nucleus Profiles and Lesion Geography in the MS Cortex
08, Oct 2026This post covers Schirmer and colleagues' 2019 Nature study, which applied single-nucleus RNA sequencing and spatial transcriptomics to cortical...
Genetics
Metabolomics and Single-Nucleus Data From the Same MS Lesion
07, Oct 2026This post covers Ladakis and colleagues' 2024 study in Neurology: Neuroimmunology & Neuroinflammation, the first metabolomic profiling of MS brain...
Genetics
What This Year's Nobel Tool Has Done in MS So Far
06, Oct 2026This post covers Absinta and colleagues' 2021 Nature study, which used the paramagnetic rim MRI biomarker to direct single-nucleus RNA sequencing...
Genetics
The Metabolite Pathway Behind the MS Severity Variant
04, Oct 2026his post covers Nataf and colleagues' 2024 study in the International Journal of Molecular Sciences, which redoes the gene prioritization for...
Genetics
MS Risk Variants, Single Cell Expression, and MRI Brain Volume
02, Oct 2026This post covers Upcott and colleagues' 2026 medRxiv preprint, which builds cell-type specific transcriptional risk scores for MS by weighting...
Genetics
A Choroid Plexus Endophenotype for HLA Burden in MS
02, Oct 2026This post covers Preziosa and colleagues' 2026 study in Neurology: Neuroimmunology & Neuroinflammation as an imaging-genetics design. It follows...
Genetics
MS Genetic Risk, Healthy Brains, and an Effect Measured in Milliseconds
29, Sep 2026This post covers Feng and colleagues' 2026 study in Magnetic Resonance in Medical Sciences, which tested whether a polygenic risk score for...
Genetics
HLA Allele, Four Measures of MS Severity
27, Sep 2026This post covers Okuda and colleagues' 2009 Brain study of HLA-DRB1*1501 carrier status against four domains of MS severity in 505 patients at...