Genetics
Multiancestry MS GWAS Meets Single-Cell and Spatial Data11, Oct 2026
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Genetics
Multiancestry MS GWAS Meets Single-Cell and Spatial Data
11, Oct 2026This post covers Fujimoto and colleagues' 2026 Nature Genetics study, the first MS GWAS in an East Asian population and a four-population...
Genetics
From an MS GWAS Locus to the Gene It Acts Through
08, Oct 2026This post covers the variant-to-gene half of Upcott and colleagues' 2026 medRxiv preprint, which paired the MS susceptibility GWAS with blood and...
Genetics
Single-Nucleus Profiles and Lesion Geography in the MS Cortex
08, Oct 2026This post covers Schirmer and colleagues' 2019 Nature study, which applied single-nucleus RNA sequencing and spatial transcriptomics to cortical...
Genetics
MS Risk Variants, Single Cell Expression, and MRI Brain Volume
02, Oct 2026This post covers Upcott and colleagues' 2026 medRxiv preprint, which builds cell-type specific transcriptional risk scores for MS by weighting...
Genetics
An MS Severity Variant Measured as Brain Atrophy
01, Oct 2026This post covers Gasperi and colleagues' 2023 Annals of Neurology brief communication, which tested whether the MS severity variant rs10191329 is...
Genetics
MS Genetic Risk, Healthy Brains, and an Effect Measured in Milliseconds
29, Sep 2026This post covers Feng and colleagues' 2026 study in Magnetic Resonance in Medical Sciences, which tested whether a polygenic risk score for...
Genetics
Genotype and the Periventricular Edge in MS
28, Sep 2026This post covers Sombekke and colleagues' 2011 AJNR exploratory study, which tested 69 candidate SNPs against voxelwise lesion probability in 208...
Genetics
Where MS Lesions Sit, Treated as a Genetic Trait
28, Sep 2026This post covers Gourraud and colleagues' 2013 Brain study, which turned the three-dimensional distribution of white matter lesions into a...
Genetics
Two Loci for How MS Progresses, Not Whether It Starts
23, Sep 2026This post covers Loomis and colleagues' 2023 Scientific Reports study, the first GWAS meta-analysis of longitudinal brain MRI measures of MS...
Genetics
Narrowing 1,091 Metabolites Down to One Enzyme in MS
23, Sep 2026This post covers Noroozi and colleagues' 2026 medRxiv preprint, a layered Mendelian randomization study testing 1,091 plasma metabolites and 309...
Genetics
A MAP1B Variant Tracks With Progressive MS in Women
21, Sep 2026This post covers Djuric and colleagues' 2025 study in International Journal of Molecular Sciences, which tested seven regulatory gene variants...
Genetics
Two Approaches to Iron in MS
20, Sep 2026This post covers Tang and colleagues' 2024 study in Frontiers in Immunology, which pairs a bioinformatics analysis of iron metabolism genes in MS...